A MXene@ Pt Nanocomposite-based Wearable Epidermal Patch for Real-time Glucose and pH Monitoring

An electrochemical epidermal patch based on the MXene@Pt nanocomposite and platinum nanoparticles (PtNPs) functionalized laser-induced graphene (LIG) electrode was newly developed for real-time and continuous glucose and pH monitoring. The MXene@Pt nanocomposite coated on the working electrode exhibited excellent conductivity, biocompatibility, and hydrophilic properties, and its layered structure significantly increased the electrochemical surface area. It also adhered effectively to the electroplated PtNPs for improving their stability and glucose sensitivity. Within the physiological sweat range (0–2 mM), the fabricated glucose sensor showed an excellent sensitivity of 86.46 μAmM−1cm−2 while the polyaniline-based pH sensor showed a near Nernstian sensitivity of -53.072 mV/pH over a pH range of 4–9 with excellent regression coefficient value (R2 = 0.99996). The combination of MXene@Pt nanocomposite and PtNPs much enhances the sensitivity of glucose detection and offers great potentials for various electrochemical sensors applications.