Trimetallic Pd@Au@Pt nanocomposites platform on -COOH terminated reduced graphene oxide for highly sensitive CEA and PSA biomarkers detection
In this paper, a trimetallic Pd@Au@Pt nanocomposites platform on -COOH terminated reduced graphene oxide(COOH-rGO) was newly developed for sensing carcinoembryonic antigen (CEA) and prostate specific antigen(PSA) biomarkers. Trimetallic electro-catalytic surfaces were prepared by the electrodeposition of noble metals(Pd@Au@Pt) nanoparticles on COOH- rGO. After EDC/NHS treatment, the anti-CEA and anti-PSA were immobilized separately on two different platforms. Under optimized conditions, the platforms were analyzed bycyclic voltammetry and differential pulse voltammetry (DPV). The platform shows good electro catalytic activity,high sensitivity, and acceptable stability for sensing CEA and PSA biomarkers. For CEA, we obtained sensitivity of 0.099 ± 0.007 μA ng−1ml, wide linear range from 12 pg ml−1to 85 ng ml−1and a limit of detection (LOD) of8pgml−1, while for PSA sensitivity is 0.267 ± 0.02 μA ng−1ml, wide linear range from 3 pg ml−1to 60 ng ml−1and LOD of 2 pg ml−1. The validation of the platform was observed through standard addition method. Thus,the sensing platform could be used for the point of care detection of CEA and PSA
Similar Publications:
Wearable electrochemical biosensors for perspiration analysis offer a promising non-invasive biomarker monitoring method. Herein, a functionalized ...
Recent advances in wearable patches have included various sensors to monitor either physiological signs, such as the heart rate and respiration rate, or meta...
In this study, an ultra-high sensitive, flexible, wireless, battery-free, and fully integrated (no external analysis equipment) electrochemical sensing patch...
Three-dimensional (3D) porous laser-guided graphene (LGG) electrodes on elastomeric substrates are of great significance for developing flexible functional e...
The patterned LIG flakes are generally not interconnected due to the line gap of the laser ray, leading to lower uniform conductivity and fragile graphene. T...
A sensitive macroporous Au electrode with a highly rough surface obtained through the use of with Pt nanoparticles (macroporous Au-/nPts) is reported. It has...